CAMPTOTHECIN DERIVATIVES WITH ANTICANCER ACTIVITY Russian patent published in 2012 - IPC C07D491/22 A61K31/4745 A61K35/00

Abstract RU 2450007 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new derivatives of 5-substituted camptothecin of formula 1 wherein R represents F, R1 represents hydrogen; R2 represents hydrogen; and R3 represents hydrogen; its pharmaceutically acceptable salts, diastereoisomers and appropriate mixtures which show anticancer activity.

EFFECT: invention refers to a method for preparing of these compounds, using them as anticancer drugs, and to pharmaceutical compositions containing them.

6 cl, 2 tbl, 22 ex

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RU 2 450 007 C2

Authors

Fontana Gabriele

Bombardelli Ehtsio

Mandzotti Karla

Battal'Ja Arturo

Samori Kristian

Dates

2012-05-10—Published

2007-07-16—Filed