FIELD: medicine.
SUBSTANCE: invention refers to new 5-substituted derivatives of thiocamptothecin of general formula 1: 
, wherein: R represents hydrogen, -N3; R1 hydrogen, ethyl, group -CH=N-O-C(CH3)3; R2 represents hydrogen, -CH2N(CH3)2; R3 represents hydrogen, hydroxyl, group 
, to their pharmaceutically acceptable salts, enantiomers, diastereoisomers and related mixtures.
EFFECT: higher anticancer activity of the compound.
10 cl, 3 tbl, 34 ex
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