METHOD OF PRODUCING N-PYRAZINOYL-L-PHENYLALANYL-L-LEUCINE BORONIC ACID OR ANHYDRIDE THEREOF Russian patent published in 2012 - IPC C07F5/02 

FIELD: chemistry.

SUBSTANCE: method involves reaction of trifluoroacetate (1S,2S,3R,5S)-pinanediol-(R)-1-ammonium-3-methylbutane-1-boronate with N-pyrazinoyl-L-phenylalanyl with ultrasonic activation using a suitable condensing agent in the presence of a suitable base. The formed (1S,2S,3R,5S)-pinanediol N-pyrazinoyl-L-phenylalanyl-L-leucine-boronate undergoes an exchange reaction with isobutyl boronic acid in an acidic medium to form N-pyrazinoyl-L-phenylalanyl-L-leucine boronic acid or anhydride thereof.

EFFECT: method enables to obtain an end product of higher purity and high output, and a more efficient and safer technique.

7 cl, 5 ex