CONNECTIONS OF SUBSTITUTED TRIAZOLBRONIC ACID Russian patent published in 2017 - IPC C07F5/02 A61K31/69 A61P29/00 A61P37/00 A61P43/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I): , wherein the residues R¹, R¹' and R¹ʺ independently represent hydrogen, alkoxy, halogen or -CF₃ group. The residue R² it represents C_1-7alkyl or phenyl, or a pharmaceutically acceptable salt thereof. Also pharmaceutical composition, using the compounds of formula I, and method of treatment are provided.

EFFECT: compounds of formula I are inhibitors immunoproteasomal subunit LMP7, and may be useful in the treatment of inflammatory diseases and disorders such as rheumatoid arthritis, lupus and irritable bowel syndrome.

13 cl, 1 tbl, 5 ex