FIELD: medicine.
SUBSTANCE: blood plasma is examined for the presence and the position of double bonds and the related differences in structural characteristics. Common and examined steroids are chemically modified by a carboxyl group (oximes); their mass spectra are read out and recorded; characteristic ions (lc) and neutral loss (Do) are specified in the mass spectra. The specified lc and Do values are related to those specific for common 3-oxosteroid oximes by the absolute value. Herewith it is only the similar lc and Do values from both sides differing by 0.3% and less that are taken into consideration; the comparison results are used to identify 3-oxosteroid oximes.
EFFECT: high accuracy of identification and classification of 3-oxosteroids and their metabolites in doping test of sportsmen, lower detection threshold, reduced amount of blood plasma required for the analysis combined with cutting analysis time.
4 tbl, 1 ex, 5 dwg
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