FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry and medicine. A composition represents a powder of a substance containing a consortium of immunoglobulins IgA, IgG and IgM and target additives able to form a stable foam structure, specified in: polyethylene glycol, albumin, gelatine, pectin, casein, caseinate, casein hydrolysate, hydroxypropyl cellulose, polyglucin, dextrin, tragacanth, aerosil, glycine, L-lysine monohydrochloride, L-arginine monohydrochloride, glucose, maltose, mannitol, lactose or their mixtures; it is characterised by porous structure and fragility, has a relative disintegration shrinkage at least 10 %, equivalent pore diameter 10-110 mcm at particle size no more than 100 mcm and a resting angle less than 50° and represented in the form of a solid capsule in the following proportions in 1.0 g of the composition: the consortium of immunoglobulins IgA, IgG and IgM 0.05-0.95 g; target additives - the rest with the capsule coated with a layer of a enterosoluble substance specified in: shellac, oleic acid, hydroxypropyl cellulose, cellulose acetate phthalate, bee wax, Tween-20, Tween-80, castor oil, polyethylene oxide or their mixture.
EFFECT: invention provides the isotropic filling of the 100% preset volume of the solid capsules that exceeds the effect of a similar composition by 5%, the maximum isotropic filling of the solid capsules ensures precise dosages of the consortium of immunoglobulins.
4 cl, 4 ex
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Authors
Dates
2012-08-10—Published
2008-08-05—Filed