FIELD: chemistry.
SUBSTANCE: invention relates to novel antibiotic oligomycin A derivatives, having anti-tumour activity and low toxicity, of formula: , where R is a methanesulphonic acid (OSO3CH3) residue or an azide group (N3) and synthesis method and use thereof.
EFFECT: obtaining novel antibiotic oligomycin A derivatives.
3 cl, 1 dwg, 1 tbl, 4 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD FOR MODIFICATION OF MACROLIDE ANTIBIOTIC OLIGOMYCIN A BY REACTION OF [3+2]-DIPOLAR CYCLOCONNECTION OF AZIDE AND ALKINES 33-DEOXY-33-(TRIAZOL-1-YL)-OLIGOMYCINS A AND THEIR BIOLOGICAL ACTIVITY | 2012 |
|
RU2523284C9 |
METHOD FOR 2,3,16,17,18,19-HEXAHYDROOLIGOMYCIN A AND ITS APPLICATION FOR INHIBITING GROWTH OF CANDIDA YEASTS | 2016 |
|
RU2623087C1 |
METHOD OF SPECIES IDENTIFICATION OF L.casei/paracasei, L.fermentum, L.plantarum AND L.rhamnosus | 2012 |
|
RU2508406C2 |
METHOD FOR ASSESSING EFFECTIVENESS OF DRUG THERAPY IN PATIENTS WITH CHRONIC HEART FAILURE | 2023 |
|
RU2818454C1 |
METHOD FOR THE PREPARATION OF 1-(2-PROPARGYL)-1H-NAPHTHO[2,3-d][1,2,3]TRIAZOLE-4,9-DIONE-4-OXIME-2-OXIDE | 2022 |
|
RU2791249C1 |
HYBRID DERIVATIVE OF LUPANE TRITERPENOID AND GALLIC ACID CONTAINING A 1,2,3-TRIAZOLE LINKER WITH ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY | 2023 |
|
RU2811236C1 |
DERIVATIVES OF OLIVOMYCIN 1, ANTIBIOTIC OF AUREOLIC ACID GROUP WITH ANTICANCER ACTIVITY, AND METHOD OF PRODUCTION THEREOF | 2007 |
|
RU2350621C1 |
APPLICATION OF CITOFLAVIN FOR TREATMENT OF TICK-BORNE NEUROINFECTIONS | 2007 |
|
RU2342131C2 |
LOW-MOLECULAR CONJUGATES OF ANTITUMOUR AGENTS AND HIGHLY SELECTIVE LIGANDS OF ASIALOGLYCOPROTEIN RECEPTOR FOR THERAPY OF ONCOLOGICAL LIVER PATHOLOGIES | 2017 |
|
RU2696096C2 |
CELL AND GENE METHODS FOR IMPROVEMENT OF CARDIAC FUNCTION | 2012 |
|
RU2608957C2 |
Authors
Dates
2012-06-27—Published
2011-03-31—Filed