CELL AND GENE METHODS FOR IMPROVEMENT OF CARDIAC FUNCTION Russian patent published in 2017 - IPC C07H21/04 C12P21/04 

FIELD: biotechnologies.

SUBSTANCE: invention relates to cell technologies. Method of improving cardiac function in mammal is described, involving: transplantation of cardiomyocytes into myocardium said mammal, wherein said cardiomyocytes contain first expression vector, containing first sequence of nucleic acid, coding R1 subunit of ribonucleotide reductase, and second expression vector, containing second sequence of nucleic acid, coding R2 subunit of ribonucleotide reductase, wherein said first and second nucleic acid sequences are functionally connected with promoter, which induces hyperexpression of R1 and R2, which provides formation of deoxy-ATP and improvement of cardiac function in mammal.

EFFECT: invention broadens capabilities of cardiac failure treatment.

27 cl, 40 dwg, 15 tbl, 51 ex