FIELD: biotechnology.
SUBSTANCE: pertussis vaccines are introduced intranasally followed by intranasal inoculation of virulent B. bronchiseptica, B. parapertussis or B. pertussis bacterium in lethal doses and the survival rate of vaccinates is determined.
EFFECT: method provides for a realistic pattern of pertussis immunity and reliable determination of quantitative characteristics of protective potency.
4 cl, 3 ex, 4 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR LYOPHILIC DRYING OF ATTENUATED BACTERIA B.PERTUSSIS, ATTENUATED BACTERIA B. PERTUSSIS, STRAIN OF ATTENUATED B. PERTUSSIS BACTERIA, VACCINE, LYOPHILIZED VACCINE PREPARATION | 2017 |
|
RU2709657C2 |
| METHODS FOR ASSESSING THE PROTECTIVE ACTIVITY AND IMMUNOGENICITY OF PERTUSSIS VACCINES IN HUMANS, THE USE OF LIVE PERTUSSIS RECOMBINANT VACCINE GamFA | 2021 |
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| ATTENUATED BACTERIA BORDETELLA PERTUSSIS, WHOOPING COUGH AGENT VACCINE | 2010 |
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| POLYPEPTIDE, RECOMBINANT POLYNUCLEOTIDE, VACCINE | 1993 |
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RU2129611C1 |
| POLYNUCLEOTIDE SEQUENCE CODING STRUCTURED PERTACTIN PROTEIN; VECTOR INCLUDING SUCH SEQUENCE; AND VACCINE COMPOSITIONS CONTAINING PERTACTIN PROTEIN OR VECTOR | 2008 |
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RU2499046C2 |
| METHOD FOR EVALUATING ANTI-WHOOPING VACCINE IMMUNOGENICITY | 2003 |
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RU2231793C1 |
| VACCINE WITH LIVE BACTERIAL ISOLATES FOR SYSTEMIC ADMINISTRATION | 2011 |
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| FRESHLY ISOLATED STRAIN OF BORDETELLA PERTUSSIS BACTERIA - PRODUCER OF A COMPLEX OF PROTECTIVE ANTIGENS FOR PRODUCTION OF CELL-FREE PERTUSSIS VACCINE | 2018 |
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RU2689903C1 |
| IMMUNOGENIC COMPOSITIONS OF Bordetella bronchiseptica | 2012 |
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RU2554480C2 |
| METHOD OF PREPARING AN ATTENUATED STRAIN OF BACTERIUM SALMONELLA AND A VACCINE | 1992 |
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