FXIa INHIBITORS, A METHOD OF THEIR PRODUCTION AND USE IN PHARMACEUTICALS Russian patent published in 2023 - IPC C07D237/14 C07D237/16 C07D401/10 C07D401/12 C07D403/10 C07D403/12 C07D405/12 A61K31/50 A61K31/501 A61P7/02 A61P9/10 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I), 35, 36, 37, 44 or 45 or its stereoisomer, pharmaceutically acceptable salt, which have the ability to inhibit the FXIa factor. In formula (I) R₁ is C_1-4 alkyl; X is halogen; R₃ represents a hydrogen atom; Y represents an oxygen atom; R₂ is selected from the group consisting of hydrogen, methyl, ethyl, phenyl, hydroxyethyl, cyclopropylmethyl, methoxyethyl, isopropyl, difluoromethyl, and CF₃CH₂-; R₄ is selected from the group consisting of phenyl, 4-fluorophenyl, 4-bromophenyl, 3-methylphenyl, 4-methylphenyl, benzyl, isopropyl, , etc.; Ar is selected from the group consisting of , , , , etc.; and R₇ represents a hydrogen atom.

EFFECT: obtaining a pharmaceutical composition for inhibiting the factor FXIa containing the said compounds and the use of the said compounds in the manufacture of a medicinal product for the treatment of diseases associated with FXIa, preferably diseases associated with thrombosis.

9 cl, 9 tbl, 56 ex