FIELD: medicine.
SUBSTANCE: invention refers to biotechnology, namely a new alpha-conotoxin PnIA analogue showing high affinity and selectivity to acetylcholine-binding protein (ACBP) form Aplysia californica. The peptide has an amino acid sequence: GCCSHPPCAANNPDYC-NH2 (SEQ ID NO:1) and contains two intramolecular disulphide bonds between Cys2 and Cys8, Cys3 and Cys16.
EFFECT: invention allows extending the range the substances which appear to be competitive antagonists of acetylcholine nicotinic receptor.
3 dwg, 1 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PEPTIDE HAVING HIGH AFFINITY TO TYPE ALPHA7 HUMAN NICOTINIC RECEPTOR AND USE THEREOF | 2011 |
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RU2455359C1 |
| ANALOGUE OF ALPHA-CONOTOXIN RGIA FOR TREATING PAIN | 2016 |
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RU2731217C2 |
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RU2473559C1 |
| PEPTIDES AND THEIR DERIVATIVES WHICH INTERACT WITH NICOTINIC ACETYLCHOLINE RECEPTOR AND SUITABLE FOR USE IN COSMETOLOGY AGAINST MIMIC AND AGE-RELATED WRINKLES | 2013 |
|
RU2524428C1 |
| POLYPEPTIDE DEMONSTRATING ANTIBACTERIAL ACTIVITY AND SUITABLE FOR OBTAINING THERAPEUTIC MEDICATIONS FOR TREATMENT OF HUMAN BACTERIAL INFECTIONS | 2010 |
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RU2434880C1 |
| PEPTIDES BINDING VASCULAR ENDOTHELIUM GROWTH FACTOR | 2019 |
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RU2739246C1 |
| ANTIBODIES AGAINST ALPHA SYNUCLEIN | 2018 |
|
RU2787039C2 |
| HEMAGGLUTININ-CONTAINING CHIMERIC VIRUS-LIKE PARTICLES, SIMILAR TO PARTICLES OF FLU VIRUS | 2010 |
|
RU2569195C9 |
| CONJUGATES OF PEPTIDE AND POLYAMINO ACID, BINDING VESSEL ENDOTHELIUM GROWTH FACTOR | 2020 |
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RU2781974C2 |
| H5 GENE, WHICH CODES A STABILIZED FORM OF THE HEMAGGLUTININ PROTEIN OF INFLUENZA A (H5N8) VIRUS, RECOMBINANT PLASMID DNA PVAX-H5, CONTAINING THE H5 GENE AND PROVIDING ITS EXPRESSION, AND A STABILIZED FORM OF THE HEMAGGLUTININ PROTEIN OF THE INFLUENZA A (H5/N8) VIRUS PRODUCED BY THE RECOMBINANT PLASMID DNA PVAX-H5 IN THE ANIMAL BODY AND INDUCING A SPECIFIC IMMUNE RESPONSE AGAINST THE HIGHLY PATHOGENIC INFLUENZA A (H5N8) VIRUS | 2024 |
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RU2832515C1 |
