FIELD: medicine.
SUBSTANCE: group of inventions refers to veterinary science and represents the dog Lyme borreliosis vaccine and methods for using it. The vaccine composition contains an immunologically effective amount of organisms of the first strain of Borrelia genospecies and an immunologically effective amount of organisms of the second strain of Borrelia genospecies. The organisms of said second strain show OspA antigen, OspB antigen, or show both OspA and OspB on the surface of its cell, while the introduction of said vaccine composition in a dog induces substantial levels of the burgdorferi 50772 (ATCC No. PTA-439) borreliacide antibodies. The vaccine composition enables inducing substantial levels of the OspA and OspC borreliacide antibodies which in turn able to sterilise infected ticks.
EFFECT: vaccine prevents B burgdorferi ss recovery from skin, serological manifestation of the infection, evident disorders in extremities/joints, erosive changes associated with the infection.
7 dwg, 17 tbl, 8 ex
| Title |
Year |
Author |
Number |
| VACCINE AGAINST LYME DISEASE IN DOGS |
2018 |
- Lafleur, Rhonda, L
- Dant, Jennifer, C
- Mogler, Mark, A
- Callister, Steven, M
- Xu, Zhichang
|
RU2785620C2 |
| UNIVERSAL VACCINE FOR TREATING AND PREVENTING LYME DISEASE APPLICABLE IN HUMAN AND VETERINARY SCIENCE, AND METHOD FOR PREPARING IT |
2008 |
- Vrzal Vladimir
- Bittner Libor
- Nepereni Irzhi
- Khumela Josef
|
RU2472525C2 |
| OSPA CHIMERIC GENES, PROTEINS AND METHODS FOR USE THEREOF |
2011 |
- Krou Brajan A.
- Livi Ian
- O'Rurk Marija
- Shvendinger Mikhel
- Dann Dzhon Dzh.
- Laft Bendzhamin Dzh.
|
RU2583289C2 |
| OspA CHIMERIC GENES, PROTEINS, AND METHODS FOR THEIR USE |
2011 |
- Krou Brajan A.
- Livi Ian
- O'Rurk Mariya
- Shvendinger Mikhel
|
RU2636455C2 |
| RECOMBINANT CHIMERIC POLYPEPTIDES, CARRYING EPITOPES OF VARIOUS IMMUNODOMINANT PROTEINS OF SPIROCHAETA OF BORRELIA BURGDORFERI SENSU LATO COMPLEX, AND SERUM DIAGNOSTIC TECHNIQUE FOR IXODIC TICK-BORNE BORRELIOSIS |
2012 |
- Beklemishev Anatolij Borisovich
- Rjabchenko Aleksandr Vladimirovich
- Karavaev Vitalij Semenovich
|
RU2514230C1 |
| CHIMERIC OSPA GENES, PROTEINS AND THEIR APPLICATION METHODS |
2011 |
- Krou, Brajan, A.
- Livi, Ian
- O'Rurk, Mariya
- Shvendinger, Mikhel
- Laft, Benzhamin Dzh.
- Dann, Dzhon Dzh.
|
RU2773402C2 |
| RECOMBINANT PLASMID DNA PROVIDING SYNTHESIS OF BORRELIA GARINII IMMUNODOMINANT PROTEIN FOR LYME-BORRELIOSIS DIAGNOSIS |
2003 |
- Beklemishev A.B.
- Ivanov I.D.
|
RU2260047C2 |
| BACTERIUM STRAIN Borrelia garinii BgVir-1 FOR PREPARATION OF DRUGS FOR DIAGNOSIS AND PROPHYLAXIS OF IXODIC MITE-BORN BORRELIOSIS AND FOR EVALUATION OF PROTECTIVE AND SPECIFIC ACTIVITY OF PROPHYLAXIS AND THERAPEUTIC AGENTS |
2005 |
- Bystritskij Leonid Dmitrievich
- Stronin Oleg Vladimirovich
|
RU2295564C2 |
| BORRELIA HYBRID PROTEIN, NUCLEIC ACID CODING THIS PROTEIN, EXPRESSING CARTRIDGE, VECTOR, METHOD AND KIT FOR DIAGNOSING LYME BORRELIOSIS, VACCINE FOR BORRELIOSIS PREVENTION |
2010 |
- Leve, Lionel'
- Mezhan-Leturner, Odil'
|
RU2549698C2 |
| NUCLEOTIDE SEQUENCE ENCODING THE DBPAG POLYPEPTIDE, ADVANTAGEOUS FOR SERODIAGNOSIS OF LYME BORRELIOSIS, PETDBPAGNH RECOMBINANT PLASMID DNA, ENCODING DBPAG COMBINED POLYPEPTIDE, RECOMBINANT BACTERIA STRAIN ESCHERICHIA COLI BL21(DE3)/PETDBPAGNH - PRODUCER OF DBPAG POLYPEPTIDE, DBPAG POLYPEPTIDE AND METHOD FOR PREPARATION THEREOF |
2017 |
- Panfertsev Evgenij Aleksandrovich
- Baranova Evgeniya Vladimirovna
- Mochalov Vladimir Vyacheslavovich
- Biketov Sergej Fedorovich
- Solovev Pavel Vladimirovich
- Gorbatov Aleksej Aleksandrovich
|
RU2681229C1 |
