CARBAMOYLOXYARYL ALKANOYL ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUND AND METHOD OF TREATING PAIN, ANXIETY AND DEPRESSION Russian patent published in 2012 - IPC C07D413/06 C07D211/58 C07D471/02 C07D401/04 C07D405/04 A61P25/24 

FIELD: chemistry.

SUBSTANCE: in general formula 1 , a cyclic ring can be selectively formed; each of R₁ and R₂ is independently selected from a group consisting of hydrogen, with a straight or branched alkyl chain having 1-6 carbon atoms and phenetyl or R₁ and R₂ together form a 5- or 6-member heterocyclic ring or R₁ and R₂ together with Ar₁ form a bicyclic ring; Ar₁ is selected from a group consisting of furanyl, thionyl, methylene dioxyphenyl and phenyl, which can be substituted with at least one identical or different substitutes selected from a group consisting of hydrogen, with a straight or branched alkyl chain having 1-6 carbon atoms, a halogen such as F, O and Br, with a straight or branched alkoxy chain, having 1-6 carbon atoms, nitro and trifluoromethyl; Z is hydrogen or fluorine, or taken together with Ar₁ forms a bicyclic ring; Ar₂ is selected from a group consisting of phenyl, methylene dioxyphenyl, pyridine pyrimidine, naphthyl, bis(fluorophenyl)methyl and quinoxaline, which can be substituted with at least one identical or different substitutes selected from a group consisting of hydrogen, with a straight or branched alkyl chain, having 1-6 carbon atoms, hydroxy, halogen, with a straight or branched alkoxy chain having 1-6 carbon atoms, nitro, acetyl, tert-butyl acetate, trifluoromethyl, amino and acetate; n is equal to 1 or 2; m is an integer from 0 to 2.

EFFECT: improved method.

26 cl, 2 dwg, 2 tbl, 87 ex