PEPTIDES INHIBITING NEURON EXOCYTOSIS Russian patent published in 2012 - IPC C07K14/705 C07K14/47 C07K7/06 C07K7/08 A61K8/64 A61Q19/08 

FIELD: medicine.

SUBSTANCE: invention refers to peptides of general formula R_r-AA-R₂ which can regulate neuron exocytosis, their mixtures and their cosmetically and pharmaceutically acceptable salts wherein AA represents a sequence of 6-40 neighbouring amino acids contained in the amino acid sequence of the protein SNAP-25 R₁ is specified in a group consisting of H or acetyl, or saturated or unsaturated, linear, branched or cyclic C₃-C₂₄acyl, or a polyethylene glycol polymer; R₂ is specified in a group consisting of amino, unsubstituted or substituted by saturated linear or branched, or cyclic C₂-C₂₄aliphatic groups provided when R₁ represents H or acetyl, R₂ is other tuhan unsubstituted amino. The invention also refers to cosmetic or pharmaceutical compositions containing such peptides, and use of such for treating the conditions which require regulation of neuron exocytosis, preferentially for skin treatment.

EFFECT: higher clinical effectiveness.

12 cl, 1 dwg, 8 ex