DIFFERENTIAL DIAGNOSTIC TECHNIQUE FOR SKIN DISEASES Russian patent published in 2012 - IPC G01N33/48 

FIELD: medicine.

SUBSTANCE: computer morphometry of dermal lymphocyte nuclei in a histological skin section from an involvement centre, planimetric characterization of the lymphocyte nuclei. It is added with determining specific density of the lymphocyte nuclei per an area unit of a section image, a perimeter and an average nucleus diameter, a form factor. If specific average density of the lymphocyte nuclei per an area unit is more than 0.0141±0.0016 (DI 0.01301; 0.01932), the average nucleus area more than 13.661+0.0802 (DI 12.912; 14.9934), the average nucleus perimeter more than 15.05+0.089 (DI 14.5178; 17.2189), the average Feret's diameter more than 4.59±0.014 (DI 4.48790; 4.9745), the average form factor less than 0.8452+0.005 (DI 0.8311; 0.8423), mycosis fungoides (MF) is diagnosed, while the absence of said variation vectors enables diagnosing chronic benign dermatosis (CBD) in the patient. The invention enables diagnosing MF or CBD or rejecting it when examining the involved tissue with high reliability.

EFFECT: method is effective, cost-saving and easily reproducible, has medical and economical effectiveness as reduces the necessity of immunohistochemical, immunocytochemical, molecular-biological and other expensive procedures in medical institutions.