DIFFERENTIAL DIAGNOSTIC TECHNIQUE FOR SEZARY'S SYNDROME AND ERYTHRODERMA ACCOMPANYING BENIGN INFLAMMATORY DERMATOSES AS SHOWN BY MORPHOMETRIC PROFILE OF ANTIGEN-PRESENTING CELLS Russian patent published in 2013 - IPC G01N33/483 G01N33/53 

FIELD: medicine.

SUBSTANCE: histological examination of injured skin biopsy materials is performed by optical microscopy, immunophenotyping of infiltrate cells. The similar histologic pattern described as corneal layer detachment, nonuniform acanthosis, severe hyperkeratosis, sudden vascular distention, dermal oedema, diffuse infiltrates with lymphocyte penetration into the epidermis, the same immunophenotype of the infiltrate cells presented by CD3⁺, CD4⁺, CD43⁺, CD45RO⁺, CD2^- CD5^- lymphocytes; the above is added with the morphometric studies of antigen-representing cells in histologic specimens of the injured skin biopsy materials; that is followed by the antigen-representing cell count per 1 mm of the epidermis length, measurement of the area and nucleocytoplasmic relation. If observing an increase of the antigen-representing cell count per 1 mm of the epidermis length in 2.8 times and more as compared to the normal value in addition to an increase of the antigen-representing cell area in 1.36 times and more as compared to the normal value and an increase of the nucleocytoplasmic relation of the antigen-representing cells in 1.65 times and more as compared to the normal value, erythroderma is diagnosed. If observing a decrease of the antigen-representing cell count in 1.3 times and more as compared to the normal value in addition to a decrease of the antigen-representing cell area in 1.9 times and more as compared to the normal value and a decrease of the nucleocytoplasmic relation of the antigen-representing cells in 2 times and more as compared to the normal value, Sezary's syndrome is diagnosed.

EFFECT: higher diagnostic accuracy of the initial clinical presentations of Sezary's syndrome accompanying the benign inflammatory dermatoses.

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