DIFFERENTIAL DIAGNOSTIC TECHNIQUE FOR LYMPHOPROLIFERATIVE DERMATOPATHIES BY MORPHOMETRIC PROFILE OF BASAL KERATINOCYTES Russian patent published in 2013 - IPC G01N33/48 G01N33/53 G01N33/483 

FIELD: medicine.

SUBSTANCE: histological examination of injured skin biopsy materials is performed by optical microscopy, immunophenotyping of infiltrate cells. If lymphomas and pseudolymphomas show a similar pattern described as manifested acanthosis, hyperkeratosis, along with dermal vascular distention, perivascular lymphohistiocytic infiltrates with lymphocytes penetrating into epidermis, as well as the same immunophenotype of the CD3⁺, CD4⁺, CD43⁺, CD45RO⁺ infiltrate cells; it is added with morphometry of basal keratinocytes in the histological preparations of the injured skin biopsy materials. It is followed by measuring their area and nucleocytoplasmic relation, and if observing an increase of the basal keratinocyte area in 1.5 times and more, and of the nucleocytoplasmic relation of basal keratinocytes in 2 times and more as compared to normal skin, skin lymphomas are diagnosed, while the unchanged morphometry of basal keratinocytes - skin pseudolymphomas.

EFFECT: use of the invention provides more accurate differential diagnosis of lymphomas and pseudolymphomas.

6 dwg, 1 tbl, 2 ex