FIELD: medicine, pharmaceutics.
SUBSTANCE: invention describes genetically modified Shigella bacteria, which have deletions or gene modifications: virG(icsA) in combination with two or more genes setAB(shET 1), senA(shET2), senB(shET2- 2), stxAB and msbB2. Obtained bacteria have three or more deletions in identified genes and can be used as vaccine strains against dysentery and diarrhea, caused by Shigella. Constructed are the following specific vaccine strains: WRSS3 (ΔsenA, ΔsenB, ΔvirG, ΔmsbB2), WRSf2G15 (ΔvirG, ΔsetAB, ΔsenA, ΔsenB, ΔmsbB2) and WRSd5 (ΔvirG, ΔstxAB, ΔsenA, ΔsenB, ΔmsbB2), on the basis of which created are immunogenic compositions, live and invasive vaccines and sets, aimed at prevention and treatment of said diseases.
EFFECT: vaccine strain by invention is safer and when used will attenuate or eliminate symptoms of high temperature and diarrhea in people.
14 cl, 12 dwg, 2 tbl
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