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IPC

A61K39/112(2006-01-01)

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Application

2015141760, 2015-10-01

(24)

Start date

2015-10-01

(22)

Actual filing date

2015-10-01

(45)

Published

2017-03-22

(72)

Inventor

Aparin Petr GennadevichLvov Vyacheslav LeonidovichKnirel Yurij AleksandrovichShashkov Aleksandr StepanovichNikolaeva Irina Aleksandrovna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauchnyj Tsentr Immunologii" Federalnogo Mediko-Biologicheskogo Agentstva Rossii

METHOD FOR PRODUCING A COMPLEX SHIGELLOSIS DRUG Russian patent published in 2017 - IPC A61K39/112

Abstract RU 2614123 C1

FIELD: pharmacy.

SUBSTANCE: method involves mixing of equal weight amounts of modified lipopolysaccharide Shigella flexneri 2a and exopolysaccharide Shigella sonnei in the buffered solution of the following composition: 0.2 M NaCl, 0.05 M Tris, 0.25% sodium deoxycholate, pH 8.3, at 80°C, followed by dialysis against the same buffered solution without sodium deoxycholate and then against deionized water followed by lyophilization. In this case the modified lipopolysaccharide Shigella flexneri 2a lipid A is partially O-deacylated. The said modified lipopolysaccharide Shigella flexneri 2a is obtained as a result of selective alkaline hydrolysis of the original lipopolysaccharide Shigella flexneri 2a.

EFFECT: invention provides a drug with low toxicity, high efficiency and bimodal specificity.

2 dwg, 3 tbl, 5 ex

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RU 2 614 123 C1

Authors

Aparin Petr Gennadevich

Lvov Vyacheslav Leonidovich

Knirel Yurij Aleksandrovich

Shashkov Aleksandr Stepanovich

Nikolaeva Irina Aleksandrovna

Dates

2017-03-22—Published

2015-10-01—Filed