FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to chemical-pharmaceutical industry and deals with method of obtaining betulin 3,28-disulfate, biologically active substance which is complement inhibitor and is of great interest for medicine. Betulin sulfation is performed in N,N-dimethylformamide with SO3-dimethylformamide complex at temperature 30-50°C for 3-4 hours, after which reaction mixture is cooled to 10-15°C, diluted with 2-fold volume of 75% water-ethanol solution, containing 4% of sodium hydroxide, inorganic part is separated, and betulin disulfate is isolated in form of sodium salt after evaporation of mother liquor, then recrystallised from ethanol.
EFFECT: improvement of ecological compatibility due to replacement of toxic elements.
1 cl, 1 ex
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