FIELD: chemistry.
SUBSTANCE: invention relates to a method of obtaining derivatives of betulin 3,28-disulfate, possessing a property of a complement inhibitor. Sulphation of betulin is carried out in N,N-dimethylformamide with a mixture of sulphamic acid and urea at a temperature of 60-70°C for 2-3 hours, product separation is carried out by cooling of the reaction mass, dilution it with water, extraction with butanol, washing with water, processing of the butanol extract with the following concentration of the butanol layer and separation of the target product. Claimed are 3 versions of processing the butanol extract.
EFFECT: improving properties of derivatives.
4 cl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
RU2468031C1 |
