FIELD: biotechnology.
SUBSTANCE: betulin sulfation is carried out in 1,4-dioxane with the mixture of sulphamic acid and urea at a temperature of 70-75°C for 3.0-3.5 hours, the product isolation is carried out by cooling the reaction mass, dilution with water, extraction with butyl or isoamyl alcohol, rinsing with water, treating the alcohol extract with subsequent concentration of the alcohol layer and isolation of the target product.
EFFECT: broadening the range of sulphating reagents for betulin sulfation, improvement of environmental friendliness of the method, expansion the range of sulfated derivatives of betulin.
4 cl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PRODUCING BETULIN 3-ACETATE-28-SULPHATE DERIVATIVES | 2014 |
|
RU2560710C1 |
| METHOD OF OBTAINING ALLOBETULINE 3-SULFATE DERIVATIVES | 2013 |
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| METHOD OF PRODUCING BETULIN 3-PROPIONATE-28-SULPHATE DERIVATIVES | 2015 |
|
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| METHOD OF PRODUCING BETULINIC ACID 3-SULPHATE DERIVATIVES | 2013 |
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RU2537562C1 |
| METHOD OF BETULIN 3-ACETATE SULPHATION | 2014 |
|
RU2569370C1 |
| METHOD OF OBTAINING ALLOBETULIN 3-SULPHATE DERIVATIVES | 2014 |
|
RU2546118C1 |
| METHOD FOR SULPHATION OF BETULIN 3-PROPIONATE | 2015 |
|
RU2571101C1 |
| METHOD OF PRODUCING BETULINIC ACID 3-SULPHATE DERIVATIVES | 2013 |
|
RU2530602C1 |
| METHOD FOR PREPARING 3,28-BETULIN DISULPHATE | 2011 |
|
RU2461561C1 |
