PREVENTIVE OR THERAPEUTIC SUBSTANCE IN CASE OF INFLAMMATORY INTESTINAL DISEASES Russian patent published in 2012 - IPC A61K31/55 A61K31/4192 A61P29/00 A61P1/04 

FIELD: medicine.

SUBSTANCE: pharmaceutical composition for prevention or treatment of inflammatory intestinal diseases (IID), which contains 7,8-dimethoxy-4(5H),10-dioxo-1H-1,2,3-triasolo[4,5-c][1]-benzazepine, or its prodrug, preferably 2-(1-isopropoxycarbonyloxy-2-methypropyl)-7,8-dimethoxy-4(5H), 10-dioxi-2H-1,2,3-triasolo[4,5-c] [1]benzazepine, or its pharmaceutically acceptable salt; respective method of prevention or IID treatment and application of said compounds for manufacturing preventive or therapeutic substance against IID. Demonstrated is efficiency of claimed pharmaceutical composition, more powerful than sulfasalazine and prednisolon with respect to said purpose, in combination with high safety. Shown are few side effects of compounds, absence of inhibition of IL-2, IL-4, IL-5, IFN-gamma, absence of weight gain restraint resulting from treatment.

EFFECT: pharmaceutical composition in accordance with claimed invention can demonstrate powerful preventive and therapeutic action, even in case of severe form of disease with resistance to conventional therapeutic agents.

28 cl, 3 dwg, 9 tbl