CISAPRID COMPOSITION OF PROLONGED RELEASE OF ACTIVE SUBSTANCE FOR ORAL ADMINISTRATION AND METHOD OF ITS PREPARING Russian patent published in 2000 - IPC

FIELD: pharmacy. SUBSTANCE: composition comprises cisaprid-(L)-tartrate, pharmaceutically acceptable components, for example, carriers and excipients and from 15% to 35% of a mixture of hydroxypropylmethylcellulose with other cellulose derivative taken among the group including hydroxypropylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxyethylmethyl-cellulose and methylcellulose of the composition mass. The mass ratio of hydroxypropylmethylcellulose and indicated cellulose derivative is from 0.33 to 3.0. The composition is prepared by mixing the indicated components. Cisaprid oral composition is used for treatment of gastrokinetic disorders and provides the release of an active component at the rate from the zero the first-order value. The indicated "pattern" of cisaprid release provides the rapid relief to patient and excludes the overdosing possibility at the following administration of the composition. EFFECT: improved properties and enhanced effectiveness of the composition. 6 cl, 4 ex