METHOD OF PRODUCING SUBSTITUTED 2,3,5,6-TETRAOXABICYCLO[2,2,1]HEPTANES Russian patent published in 2013 - IPC C07D493/08 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing substituted 2,3,5,6-tetraoxabicyclo[2.2.1]heptanes of formula I where R is adamantyl, unsubstituted or substituted benzyl, unsubstituted or substituted C1-C6 alkyl, wherein the substitutes can be CN, COOMe, COOEt or a CH₂=CH group, R₁ is a lower alkyl or hydrogen, R₂ is a C1-C6 alkyl, which can be used in polymer chemistry, as well as in medicine and pharmacology. The method involves reaction of the corresponding β-diketones of general formula II where R, R₁ and R₂ have values given above, with hydrogen peroxide in the presence of an acid catalyst which is phosphomolybdic acid, in a medium of an organic solvent - acetonitrile, with molar ratio β-diketone: hydrogen peroxide: phosphomolybdic acid 1:3-5:0.1-0.3.

EFFECT: method increases safety and simplifies the process of producing end products and increases output thereof.

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