FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing optically active compounds: (S)-(-)-2-(N-propylamino)-5-methoxytetraline and (S)-(-)-2-(N-propylamino)-5-hydroxytetraline. Said method involves optical separation of a mixture of enantimers of 2-(N-propylamino)-5-methoxytetraline and 2-(N-propylamino)-5-hydroxytetraline in the presence of an optically active form of N-(3,5-dinitrobenzoyl)-α-phenylglycine. The method enables to obtain a product with high optical purity.
EFFECT: invention also relates to use of salts of (S)-(-)-2-(N-propylamino)-5-methoxytetraline and (S)-(-)-2-(N-propylamino)-5-hydroxytetraline as intermediate compounds when producing rotigotine.
7 cl, 6 ex
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