POLYMER CARRIER OF DRUG PREPARATIONS FOR VISUALLY-ASSISSTED DELIVERY Russian patent published in 2013 - IPC A61K41/00 A61K49/12 A61K49/18 A61K9/133 A61K47/48 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a contrast agent for magnetic-resonant tomography (MRT) based on a chemical exchange saturation transfer (CEST). The contrast agent contains polymersome provided by a paramagnetic substance, and a bilayer of an amphiphilic block copolymer or terpolymer comprising a cavity. In said cavity, there is a proton analyte pool containing water. The paramagnetic substance represents a paramagnetic chemical shift reagent containing a metal complex having a metal ion and a multidentate chelating ligand wherein the enclosure allows proton analyte diffusion. The invention also refers to a carrier of a drug preparation containing said contrast agent which is suitable for localised drug delivery. There is also declared a method for target MRT delivery of a bioactive substance into the patient which involves the stages of introducing the carrier of the drug preparation, performing MRT with using intensified CEST contrast, and enabling the carrier releasing the bioactive substance.

EFFECT: invention provides higher contrast, prolonged circulation and lesser tend to macrophage absorption.

9 cl, 7 dwg, 1 ex