FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to compounds of formula (I) or to its pharmaceutically acceptable salts: 
wherein: R1 means H, OH, halogen, C1-C6alkyl, C1-C6alkoxy, halogenC1-C6alkyl, halogenC1-C6alkoxy, phenyl; R2a and R2b are identical or different, and mean H, halogen, C1-C6alkyl, C1-C6alkoxy, halogenC1-C6alkyl, halogenC1-C6alkoxy; R3 means C1-C6alkyl; A means a single bond, a vinylene group; B means a single bond; Ar means phenyl optionally substituted by halogen, CN, C1-C6alkyl, C1-C6alkoxy, halogenC1-C6alkyl, halogenC1-C6alkoxy; Z means -COOH, tetrazolyl; m is equal to 0, 1,2, 3, 4, 5, 6; n is equal to 0 or 1.
EFFECT: compounds exhibit calcium-sensing receptor (CaSR) antagonist activity that enables them to be used in treating or preventing a disorder related to disturbed bone or mineral homeostasis, such as osteoporosis.
18 cl, 151 tbl, 190 ex
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