NOVEL LOW-MOLECULAR CATIONIC LIPIDS FOR DELIVERY OF OLIGONUCLEOTIDES Russian patent published in 2017 - IPC C07C211/16 C07C211/21 C07C211/25 C07D207/06 A61K47/18

Abstract RU 2617641 C2

FIELD: pharmaceutics.

SUBSTANCE: present invention relates to novel cationic lipid of formula A or its any pharmaceutically acceptable salt, which are used to generate lipid nanoparticles (LNP) for delivery of oligonucleotides, to composition of lipid nanoparticles (LNP) containing disclosed cationic lipid and to use of cationic lipid. In formula A values R¹, R², R³, R', Rʺ, n, L₁ and L₂ are such as specified in patent claim.

EFFECT: novel low-molecular cationic lipids for delivery of oligonucleotides are described.

10 cl, 14 dwg, 2 tbl, 9 ex

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RU 2 617 641 C2

Authors

Stenton Mettyu Dzh.

Badzik Brajan V.

Byutner Gregori L.

Lyao Khunbyao

Dates

2017-04-25—Published

2011-09-20—Filed