STRUCTURE BASED ON PROTEIN PAIR OF BARNASE-BARSTAR AND METHOD OF ITS PRODUCTION Russian patent published in 2013 - IPC C12N9/22 B82B1/00 B82B3/00 B82Y5/00 B82Y40/00 

FIELD: biotechnologies.

SUBSTANCE: method is proposed to develop the specified structure, which includes: a) development of at least two modules, where each module is independently made in the form of a nucleus that carries molecules of the first protein and the second protein on the surface, where the first protein is barnase, and the second protein is barstar, besides, the first or second protein for binding with each module is selected in the following manner: the first module is made as carrying protein molecules on its surface selected from the first protein or the second protein; the second module is performed as carrying protein molecules on the surface selected from the first protein or the second protein and different from the protein contained in the first module; the third and each subsequent module carries molecules of either the first or the second protein on the surface; b) combination of the first, second and subsequent modules, in which modules are self-assembled in the structure due to interaction of the molecules of barnase and barstart, besides, nuclei of at least two of the specified modules are made with particles of supermolecular nature. The structure is described for diagnostics and therapy produced by the specified method.

EFFECT: invention makes it possible to produce structures including nuclei of different nature and size connected to each other by means of a functional pair barnase-barstar, providing for tight connection of the specified nuclei.

20 cl, 5 dwg, 8 ex