FIELD: medicine.
SUBSTANCE: invention refers to medicine, namely to physiology and space medicine. The method for prevention of skeletal muscle atrophy after functional unloading involves administering 17-(allylamino)-17-demethoxygeldanamycin (17-AAG) which increases an amount of muscle heat shock proteins and further reduces a level µ-calpain.
EFFECT: invention enabling managing the negative effects of hypokinesia or gravity unloading through the enhanced inhibition key signalling pathways initiating atrophy.
9 dwg
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