FIELD: medicine.
SUBSTANCE: factor reducing type 1 calpain expression is presented by a muscular administration of the preparation of PD150606 (a synonym of (2Z)-3-(4-iodophenyl)-2-mercapto-2-Propenoic acid, 3-(4-iodophenyl)-2-mercapto-(Z)-2-propenoic acid, of empirical expression C9H7IO2S) blocking the type 1 calpains in the muscles, and particularly reducing the µ-calpain iRNA expression in the muscles.
EFFECT: preventing the muscle atrophy for a long period of time by blocking the calpain proteolytic system leading to the protein breakdown accompanying the functional muscle discharge, which leads to prevention of atrophic processes.
6 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREVENTING AND REDUCING DESTRUCTION OF SKELETAL PROTEINS OF ATROPHIED SKELETAL MUSCLES CAUSED BY HYPOKINESIA AND/OR DISCHARGE BY GRAVITY | 2013 |
|
RU2517576C1 |
| METHOD FOR PREVENTION OF SKELETAL MUSCLE ATROPHY AFTER FUNCTIONAL UNLOADING | 2012 |
|
RU2481105C1 |
| USE OF VX 745 TO PREVENT SKELETAL MUSCLE ATROPHY WITH FUNCTIONAL DISCHARGE | 2019 |
|
RU2714923C1 |
| METHOD FOR PREVENTING AND REDUCING DESTRUCTION OF CYTOSKELETAL PROTEINS OF ATROPHIED SKELETAL MUSCLES CAUSED BY HYPOKINESIA AND/OR DISCHARGE BY GRAVITY | 2010 |
|
RU2444354C2 |
| METHOD OF PREVENTING ATROPHY OF SKELETAL MUSCLES DURING THEIR FUNCTIONAL UNLOADING | 2022 |
|
RU2797216C1 |
| INHIBITOR OF EXERTIONAL CYTOSKELETAL PROTEOLYSIS OF SKELETAL MUSCLES | 2008 |
|
RU2389486C1 |
| METHOD TO PREVENT DEVELOPMENT OF SKELETAL MUSCLE FATIGUE | 2023 |
|
RU2814077C1 |
| METHOD OF PREVENTING CYTOSCELETAL PROTEINS DESTRUCTION IN SCELETAL MUSCLES WITHIN ECCENTRIC LOAD | 2008 |
|
RU2391968C1 |
| METHOD OF DETERMINING THE RISK OF MALIGNANT TRANSFORMATION OF EPITHELIAL CELLS OF THE LARYNX IN PATIENTS WITH PRECANCEROUS DISEASES OF THE LARYNX | 2022 |
|
RU2803858C1 |
| METHOD FOR EVALUATING THE DEGREE OF RISK OF ADVERSE EVALUATION OF DISEASE IN PATIENTS WITH GASTRIC CANCER | 2016 |
|
RU2662085C1 |
