PYRIDINE THIO-DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAID DERIVATIVE AND CAPABLE OF ACTING AGAINST HELICOBACTER PYLORI Russian patent published in 2013 - IPC C07D401/12 A61K31/4439 A61P1/04 A61P31/04 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a pyridine thio-derivative of general formula (I) or pharmaceutically acceptable salts thereof: , where R₁ and R₂, respectively, denote a hydrogen atom; R₃ and R₄, respectively, denote a hydrogen atom or a C_1-8alkyl group; X denotes -O- or -S-; Y denotes a C_1-12alkyl group, which can be substituted with a substitute selected from a group consisting of a hydroxyl group, C_1-8alkoxy group or -(R⁵-O)_n-R⁶ (where R⁵ denotes a C_1-5alkylene group, R⁶ denotes a C_1-8-alkyl group which can be substituted with a halogen atom, and n denotes an integer from 1 to 2) and Z denotes a hydrogen atom. The invention also relates to pharmaceutical compositions based on said compounds, having antibacterial activity towards Helicobacter pyroli.

EFFECT: obtaining novel compounds and a pharmaceutical composition based on said compounds, which can be used in medicine to prevent or treat diseases in which Helicobacter pylori participates, specifically gastritis, gastric ulcers, duodenal ulcers, gastric MALT lymphoma, hyperplastic gastric polyps or gastrointestinal malignant diseases.

10 cl, 3 tbl, 14 ex