FIELD: medicine.
SUBSTANCE: what is presented is a method for prediction the efficacy of the anti-TNF therapy in the patients with rheumatoid arthritis on the basis of genetic typing the polymorphisms of TNF-alpha proinflammatory cytokine. The allelic polymorphism of the TNF-alpha gene promoter is studied in position 857. If the heterozygous state (genotype - 857ST) or the homozygous T allele carriers (genotype - 857TT) is identified, a high probability of the successful infliximab therapy is predicted. If identifying the homozygous allele C carrier in position - 857 of the TNF-alpha gene promoter (genotype - 857SS), a high probability of the failed infliximab therapy is predicted.
EFFECT: invention enables the rapid and effective prediction of the clinical outcome of the anti-TNF therapy in the patients with rheumatoid arthritis by one polymorph position.
2 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DIAGNOSTIC TECHNIQUE FOR NUTRITIONAL INSUFFICIENCY ACCOMPANYING ULCERATIVE COLITIS | 2014 |
|
RU2549464C1 |
| METHOD FOR PROGNOSIS OF TREATMENT EFFECTIVENESS WITH RECOMBINANT CYTOKINE REGULATING INFLAMMATION | 2004 |
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| METHOD FOR PREDICTION OF EFFECTIVENESS OF TREATMENT OF RHEUMATOID ARTHRITIS WITH DRUG OLOKIZUMAB BASED ON GENOTYPING | 2020 |
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| METHOD FOR PREDICTION OF CLINICAL EFFECTIVENESS IN CHRONIC PURULENT RHINOSINUSITIS | 2008 |
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| METHOD OF IMMUNOTHERAPY OF PURULENT RHINOSINUSITIS | 2010 |
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| METHOD OF TREATING CHRONIC RHINOSINUSITIS | 2011 |
|
RU2469737C1 |
| METHOD FOR PREDICTION OF EFFICACY OF INFLIXIMAB INCLUSION IN THERAPY OF PATIENTS WITH RHEUMATOID ARTHRITIS | 2010 |
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| METHOD OF TREATING CHRONIC ADENOIDITIS IN CHILDREN | 2011 |
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| METHOD FOR PREDICTING THE EFFICIENCY OF THERAPY WITH INTERLEUKIN-1 | 2005 |
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| METHOD FOR PREDICTING EFFECTIVENESS OF TREATMENT OF RHEUMATOID ARTHRITIS WITH DRUG OLOKIZUMAB USING EPIGENETIC MARKERS | 2020 |
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RU2749248C1 |
