METHOD OF TREATING CHRONIC ADENOIDITIS IN CHILDREN Russian patent published in 2013 - IPC A61K31/57 A61K31/58 A61K38/20 A61P11/02 G01N33/50 

FIELD: medicine.

SUBSTANCE: invention refers to medicine. What is presented is a method of treating chronic adenoiditis in children. A real-time polymerase chain reaction is used to analyse the blood serum concentrations of interleukine-1β and interleukine-4. Observing the C/C genotype of interleukine-1β gene in locus 3954 in a combination with the C/C or C/T genotype of interleukine-4 gene in locus 589 enables diagnosing a severe clinical course of chronic adenoiditis with frequent aggravations, complications requiring the treatment including intranasal inhalations of the suspension of mometasone 50-100 mcg per a procedure into each nasal passage 1-2 times a day 100-400 mcg daily for 30 days. Observing the C/T genotype of interleukine-1β gene in locus 3954 in a combination with the C/C or C/T genotype of interleukine-4 gene in locus 589 enables diagnosing a moderate severity of chronic adenoiditis with aggravated recurrences that requires the treatment including intranasal inhalations of the suspension of mometasone 50 mcg per a procedure into each nasal passage 1 time a day 100 mcg daily for 21-30 days. Observing the T/T genotype of interleukine-1β gene in locus 3954 in a combination with the C/C or C/T genotype of interleukine-4 gene in locus 589 enables diagnosing a mild severity of chronic adenoiditis with a mild clinical course and a favourable outcome, treated by intranasal lyophilised interleukine-1β in physiological solution 5-10 ng/ml per a procedure into each nasal passage once a day with a daily dose to be increased by 5-10 ng/ml every 1-2 days, but no more than 30 ng/ml for 5-16 days.

EFFECT: invention provides stratifying the risk groups with chronic adenoiditis and provides the effective method of treating chronic adenoiditis in children.

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