COMPOUNDS AND METHODS FOR KINASE MODULATION AND INDICATIONS FOR USE OF SAID COMPOUNDS AND METHODS Russian patent published in 2013 - IPC C07D213/75 C07D215/38 C07D231/40 C07D261/14 C07D285/16 C07D401/12 C07D407/12 C07D413/12 C07D417/12 C07D471/04 A61K31/165 A61K31/437 A61K31/444 A61K31/47 A61K31/5377 A61P35/00 

FIELD: chemistry.

SUBSTANCE: disclosed is a compound having chemical formula or a salt thereof, where: Ar is an optionally substituted heteroaryl; R¹ in each case is independently selected from a group which includes halogen, lower alkyl, optionally substituted with one or more substitutes selected from fluorine, lower alkoxy, fluorine-substituted lower alkoxy, monoalkylamino, dialkylamino, -O-R⁵, -N(R⁵)-R⁶ and -N(R⁵)-C(X)-R⁷; m equals 0 or 1; n equals 0, 1 or 2; R² is hydrogen or a halogen; L₂ is -S(O)₂-; R³ is a lower alkyl, optionally substituted with fluorine, C_3-6 cycloalkyl, optionally substituted with a lower alkyl, a 5- or 6-member nitrogen-containing heterocycloalkyl, optionally substituted with one or more substitutes selected from fluorine, lower alkyl, fluorine-substituted lower alkyl, lower alkoxy, fluorine-substituted lower alkoxy, lower alkylthio or fluorine-substituted lower alkylthio, aryl, optionally substituted with a halogen, lower alkyl, optionally substituted with a halogen or lower alkoxy, optionally substituted with a halogen, or a heteroaryl, optionally substituted with a halogen or a lower alkyl; L₁ is selected from a group which includes -O-, -C(R¹²R¹³)-X-, -X-C(R¹²R¹³)-, -C(R¹²R¹³)-N(R¹¹)-, -(R¹¹)-C(R¹²R¹³)-, -C(X)-N(R¹¹)-, -N(R¹¹)-C(X)-; X is O; R¹¹ is hydrogen; R⁴ is hydrogen or a lower alkyl; R⁵ and R⁶ in each case are independently selected from a group which includes hydrogen, lower alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, where each is optionally substituted with one or more substitutes selected from fluorine, lower alkoxy, fluorine-substituted lower alkoxy, lower alkylthio, fluorine-substituted lower alkylthio, monoalkylamino, dialkylamino; R⁷ in each case is independently selected from a group which includes lower alkyl; where the terms "lower alkyl", "lower alkoxy", "lower alkylthio", "monoalkylamino", "dialkylamino", "cycloalkyl", "heterocycloalkyl", "aryl", "heteroaryl", are as described in the claim. The invention also discloses a pharmaceutical composition for treating Raf kinase mediated diseases which is based on a compound of formula I; use of the compound of formula I to produce a medicinal agent is also disclosed.

EFFECT: novel compound which can be useful in treating diseases and conditions associated with aberrant activity of protein kinases is obtained and described.

9 cl, 13 ex, 2 tbl