COMPLEXES OF GERMANIUM WITH PURINE NITROGENOUS BASES, METHODS FOR PRODUCTION THEREOF AND MEDICINAL AGENTS CONTAINING SAID COMPLEXES Russian patent published in 2013 - IPC C07F7/30 A61K31/28 A61P31/22 A61P37/04 

Abstract RU 2487878 C1

FIELD: chemistry.

SUBSTANCE: disclosed are germanium complexes, having a general structural formula (I): Gex[AD][CA]y[AA]z (I), where AD denotes a purine nitrogenous base derivative, having antiviral activity; CA denotes a hydroxycarboxylic acid; AA denotes an amino acid selected from α-amino acids, where x=1÷2, y=2÷4, z=0÷2, wherein all CA in the complex are identical or different, all AA in the complex are identical or different. Also disclosed is a method of producing germanium complexes, a medicinal agent and an immunostimulant.

EFFECT: invention enables to obtain germanium complexes, having high antiviral and immunostimulating activity.

18 cl, 5 dwg, 3 tbl, 7 ex

Similar patents RU2487878C1

Title Year Author Number
2-AMINO-5,6-DIFLUOR-1-(BETA-D-RIBOFURANOSYL)-BENZIMIDAZOLE, METHOD FOR PRODUCTION AND ANTIVIRAL ACTIVITY IN TERMS OF HERPES SIMPLEX VIRUS TYPE I 2016
  • Konstantinova Irina Dmitrievna
  • Kharitonova Mariya Igorevna
  • Miroshnikov Anatolij Ivanovich
  • Kotovskaya Svetlana Konstantinovna
  • Charushin Valerij Nikolaevich
  • Galegov Georgij Artemevich
  • Andronova Valeriya Lvovna
RU2629670C2
PHOSPHONATE DERIVATIVES OF ACICLOVIR AND METHOD FOR THEIR PREPARING 2003
  • Galegov G.A.
  • Andronova V.L.
  • Skoblov Ju.S.
  • Jas'Ko M.V.
  • Kukhanova M.K.
  • Karpenko I.L.
  • Ivanov A.V.
RU2239638C2
DIMERIC DERIVATIVE OF NETROPSIN - 15-LYS-BIS-NETROPSIN AND COMBINATIONS BASED ON THEREOF POSSESSING ANTI-HERPETIC ACTIVITY 2004
  • Galegov G.A.
  • Andronova V.L.
  • Gurskij G.V.
  • Surovaja A.N.
  • Grokhovskij S.L.
RU2265610C1
-4-[6-(PURINE-6-YLAMINO)HEXANOYL]-3,4-DIHYDRO-3-METHYL-7,8-DIFLUOR-2H-[1,4]BENZOXAZINE AND (3R)-4-[6-(PURINE-6-YLAMINO)HEXANOYL]-3,4-DIHYDRO-3-METHYL-7,8-DIFLUOR-2H-[1,4]BENZOXAZINE WITH ANTIVIRAL ACTIVITY 2016
  • Musiyak Vera Vasilevna
  • Galegov Georgij Artemevich
  • Andronova Valeriya Lvovna
  • Krasnov Viktor Pavlovich
  • Levit Galina Lvovna
  • Gruzdev Dmitrij Andreevich
  • Chulakov Evgenij Nikolaevich
  • Charushin Valerij Nikolaevich
RU2644351C1
4,6-DI(3,12-DIAZA-6,9-DIAZONIADISPIRO[5,2,5,2]HEXADECAN-1-YL)-2-METHYL-5-NITROPYRIMIDINE TETRACHLORIDE HYDROCHLORIDE HEXAHYDARATE FOR TREATING HERPETIC INFECTION, PHARMACEUTICAL COMPOSITION FOR LOCAL APPLICATION 2014
  • Makarov Vadim Albertovich
  • Monakhova Natalya Sergeevna
  • Ryabova Olga Borisovna
RU2573977C9
IMMUNOCORRECTIVE AGENT FOR TREATING DISEASES OF VIRAL AETIOLOGY 2007
  • Malinovskaja Valentina Vasil'Evna
  • Vardanjan Nina Vasil'Evna
  • Vyzhlova Evgenija Nikolaevna
RU2411039C2
N-[5-(AMINOSULPHONYL)-4-METHYL-1,3-THIAZOL-2-YL]-N-METHYL-2-[4-(2-PYRIDINYL)PHENYL]ACETAMIDE MONOHYDRATE 2012
  • Schwab, Wilfried
  • Birkmann, Alexander
  • Voegtli, Kurt
  • Haag, Dieter
  • Lender, Andreas
  • Grunenberg, Alfons
  • Keil, Birgit
  • Rehse, Joachim
RU2669388C1
COMBINATIONS BASED ON NETROPSIN OR ITS BIS-DERIVATIVE ELICITING ANTI-HERPETIC ACTIVITY 2002
  • Galegov G.A.
  • Andronova V.L.
  • Gurskij G.V.
  • Surovaja A.N.
  • Grokhovskij S.L.
RU2240792C2
INCLUSION COMPOUND OF 9-(2-HYDROXYETHOXYMETHYL)GUANINE WITH BETA- CYCLODEXTRINE MANIFESTING ANTIHERPES ACTIVITY 1996
  • Jurkevich A.M.
  • Volosjuk T.P.
  • Galegov G.A.
  • Reshetnjak V.Ju.
  • Kukljushkina M.V.
RU2128664C1
4-((Z)-4'-HYDROXYBUTENE-2'-YL)-2-R-6-FURYL-1,2,4-TRIAZOLO[5,1-c][1,2,4]TRIAZINE-7-ONS 2008
  • Chupakhin Oleg Nikolaevich
  • Rusinov Vladimir Leonidovich
  • Ulomskij Evgenij Nartsissovich
  • Charushin Valerij Nikolaevich
  • Shestakova Tat'Jana Sergeevna
  • Deev Sergej Leonidovich
  • Rusinova Larisa Ivanovna
  • Andronova Valerija L'Vovna
  • Galegov Georgij Artem'Evich
  • Karpenko Inna Leonidovna
  • Jas'Ko Maksim Vladimirovich
  • Kukhanova Marina Konstantinovna
RU2376307C1

RU 2 487 878 C1

Authors

Isaev Aleksandr Dmitrievich

Ambrosov Igor' Valer'Evich

Manasherov Tamaz Omarovich

Matelo Svetlana Konstantinovna

Dates

2013-07-20Published

2012-05-16Filed