FIELD: medicine.
SUBSTANCE: method consists in determining a percentage of immunoglobulin G and M coated platelets using flow cytometry. For the purpose of the analysis, own patient's platelets and blood serum are examined; autoimmune process markers are immunoglobulin G and M antibodies. A platelet autosensitisation index is calculated as ratio of Anti-Human IgG/IgM-positive cells to CD41 fixing cells: the platelet autosensitisation index more than 2% without autoserum incubation and more than 5% after autoserum incubation is considered as the presence of the antiplatelet autoantibodies fixed on cells and/or circulating in blood plasma.
EFFECT: higher diagnostic accuracy of immune thrombocytopenia, specifying a therapeutic approach and controlling the effectiveness thereof.
3 tbl, 2 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD FOR THE DIAGNOSIS OF ALLOIMMUNE THROMBOCYTOPENIA OF THE NEWBORN | 2015 |
|
RU2611348C1 |
METHOD FOR DIAGNOSING ALLOIMMUNE THROMBOCYTOPENIA OF NEWBORNS | 2022 |
|
RU2817215C2 |
METHOD FOR DIAGNOSING NEONATAL IMMUNE NEUTROPENIA | 2021 |
|
RU2781474C1 |
CD40L ANTAGONIST AND METHODS OF ITS USE | 2019 |
|
RU2812919C2 |
METHOD FOR ESTIMATION OF ALUMINIUM INFLUENCE ON IMMUNE STATUS | 2016 |
|
RU2629597C1 |
METHOD FOR EARLY DIAGNOSIS OF RHEUMATOID ARTHRITIS | 2019 |
|
RU2735738C1 |
METHOD OF DIAGNOSTICS OF PREECLAMPSIA ATTACHMENT IN PREGNANT WOMEN WITH CHRONIC ARTERIAL HYPERTENSION | 2016 |
|
RU2652447C1 |
METHOD FOR DIAGNOSIS OF AUTOIMMUNE LIVER INJURY IN PATIENT WITH CHRONIC HEPATITIS | 2003 |
|
RU2247387C1 |
METHOD FOR DIAGNOSING ALLERGIC BRONCHIAL ASTHMA | 2021 |
|
RU2780687C1 |
DIAGNOSTIC TECHNIQUE FOR PREECLAMPSIA IN PREGNANT WOMEN SUFFERING CHRONIC ARTERIAL HYPERTENSION | 2014 |
|
RU2561060C1 |
Authors
Dates
2013-07-20—Published
2012-01-10—Filed