5,5-CONDENSED ARYLENE OR HETEROARYLENE HEPATITIS C VIRUS INHIBITORS Russian patent published in 2015 - IPC C07D487/04 C07D491/48 C07D495/04 C07D498/04 C07D513/04 A61K31/429 A61K31/424 A61K31/4188 A61P31/12 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to 5,5-condensed heteroarylene compounds IIIB, where U², V¹, V² and W¹ are selected from O, N, NH, S or CR^3a; U¹, W², X¹ and X² represent C or N; R¹ and R² represents hydrogen, -C(O)CH(NR^1bR^1c)R^1a, -C(O)CH(N(R^1c)C(O)OR^1b)R^1a or -C(O)OR^1a; R^3a represents hydrogen or R³; R³ represents halogen or -C(O)OR^1a; L¹ and L² are such as given in invention formula, each Z¹ and Z² represents bond or -O-; each R^la, R^1b and R^1c represents hydrogen, C_1-6 alkyl or C_6-14 aryl; or R^lb and R^lc together with N atom, which they are bound to, form 5-6-membered heterocyclyl; q, r, s, t and u equal 1. Invention also relates to pharmaceutical compositions, containing 5,5-condensed heteroarylene compounds, and methods of treating or preventing HCV infection.

EFFECT: 5,5-condensed heteroarylene derivatives, possessing inhibiting activity with respect to hepatitis C virus.

43 cl, 42 ex