BENZIMIDAZOLE DERIVATIVES AS ERBB TYROSINE KINASE INHIBITORS FOR TREATING CANCER Russian patent published in 2021 - IPC C07D401/14 C07D405/14 C07D403/04 C07D403/14 C07D409/14 A61K31/4184 A61K31/55 A61P35/00

Abstract RU 2741914 C2

FIELD: organic chemistry.

SUBSTANCE: invention relates to a heterocyclic compound of formula IV or a pharmaceutically acceptable salt thereof, wherein L¹-L² is , where R¹ is a substitute for nitrogen; Z is -NH-; R¹ is selected from: and ; R² is methylpyridinyl or trifluoromethylpyridinyl; R⁴ denotes hydrogen; R⁵, R⁶ and R⁷ are selected from hydrogen, halogen and -OR^1a, provided that one of R⁵, R⁶ and R⁷ is -OR^1a; and R^1a is selected from trifluoromethyl,

. Invention also relates to specific compounds of formulas D1 and D8, a pharmaceutical composition based on said compounds and a method of treating, preventing or alleviating said diseases.

EFFECT: obtaining novel benzimidazole derivatives effective in treating cancer.

15 cl, 2 tbl, 30 ex

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RU 2 741 914 C2

Authors

Long, Yun

Dates

2021-01-29—Published

2015-03-19—Filed