FIELD: organic chemistry.
SUBSTANCE: invention relates to a heterocyclic compound of formula IV or a pharmaceutically acceptable salt thereof, wherein L1-L2 is , where R1 is a substitute for nitrogen; Z is -NH-; R1 is selected from:
and
; R2 is methylpyridinyl or trifluoromethylpyridinyl; R4 denotes hydrogen; R5, R6 and R7 are selected from hydrogen, halogen and -OR1a, provided that one of R5, R6 and R7 is -OR1a; and R1a is selected from trifluoromethyl,
. Invention also relates to specific compounds of formulas D1 and D8, a pharmaceutical composition based on said compounds and a method of treating, preventing or alleviating said diseases.
EFFECT: obtaining novel benzimidazole derivatives effective in treating cancer.
15 cl, 2 tbl, 30 ex
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Authors
Dates
2021-01-29—Published
2015-03-19—Filed