FIELD: medicine.
SUBSTANCE: what is presented is a method for prediction of the clinical course of non-Hodgkin lymphomas involving the DNA recovery from peripheral venous blood lymphocytes, PCR and restriction of the amplification products. That is followed by genetic typing of the polymorphous locus 309T>G of MDM2 gene. If observing the genotype TT in the patient, the indolent form of non-Hodgkin lymphomas if predicted; the genotype TG shows the aggressive form of non-Hodgkin lymphomas, and the genotype GG testifies to the highly aggressive form of the non-Hodgkin lymphomas.
EFFECT: providing an additional criterion for the assessment and prediction of the clinical course of non-Hodgkin lymphomas.
1 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREDICTION OF DEVELOPING B CELL AND T CELL NON-HODGKIN LYMPHOMAS | 2012 |
|
RU2490638C1 |
| METHOD FOR PREDICTION OF CLINICAL FORM OF CHRONIC LYMPHOLEUKAEMIA | 2012 |
|
RU2490642C1 |
| METHOD FOR PREDICTING THE DEVELOPMENT AND FLOW OF CHRONIC LYMPHOLEUKOSIS | 2003 |
|
RU2248574C1 |
| METHOD FOR PROGNOSIS OF MULTIPLE MYEOLOMA COURSE | 2002 |
|
RU2225612C2 |
| METHOD OF DETERMINING PERSON'S PREDISPOSAITION TO DEVELOPMENT OF AGGRESSIVE NON-HODGKIN'S LYMPHOMAS | 2008 |
|
RU2373862C1 |
| METHOD FOR PREDICTING THE FLOW OF MULTIPLE MYELOMA | 2005 |
|
RU2282852C1 |
| METHOD FOR PREDICTION OF SMOULDERING FORM OF CHRONIC LYMPHOLEUKAEMIA | 2012 |
|
RU2496110C1 |
| METHOD FOR PREDICTION CHEMOTHERAPEUTIC RESPONSE IN CHRONIC LYMPHATIC LEUKAEMIA | 2012 |
|
RU2495427C1 |
| METHOD FOR PREDICTING RISK OF PROGRESSION OF PRIMARY NON-HODGKIN'S LYMPHOMAS WITH BONE MARROW INVOLVEMENT | 2016 |
|
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| METHOD OF PREDISPOSITION TO ONCOPATHOLOGY DETERMINATION | 2018 |
|
RU2694231C1 |
