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2 491 950

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IPC

A61K36/53(2006-01-01)

A61K31/235(2006-01-01)

A61P29/00(2006-01-01)

C07C13/48(2006-01-01)

(21) (22)

Application

2012126841/15, 2012-06-27

(24)

Start date

2012-06-27

(22)

Actual filing date

2012-06-27

(45)

Published

2013-09-10

(72)

Inventor

Kozlov Sergej AleksandrovichOsmakov Dmitrij IgorevichAndreev Jaroslav AlekseevichKoshelev Sergej Gennad'EvichGrishin Evgenij Vasil'EvichD'Jachenko Igor' AleksandrovichBondarenko Dmitrij AleksandrovichMurashev Arkadij Nikolaevich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Institut Bioorganicheskoj Khimii Im. Akademikov M.M. Shemjakina I Ju.A. Ovchinnikova Rossijskoj Akademii Nauk Ran)

LIGNAN, POSSESSING ANALGESIC ACTION Russian patent published in 2013 - IPC A61K36/53 A61K31/235 A61P29/00 C07C13/48

Abstract RU 2491950 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry, namely to biologically active compound, which has analgesic action. Lignan, which has analgesic action, whose structure is described as (1R,2S)-1-[(1R,2S)-1-(3,4-dihydroxyphenyl)-6,7-dihydroxy-3 - [(1R,2S)-1,2,3-tricarboxypropoxy]carbonyl-1,2-dihydronaphthalene-2-carbonyl]oxypropane-1,2,3-tricarboxylic acid: .

EFFECT: lignan has directed action at proton-driven ion channel ASIC3, which initiates neuronal response under pain stimuli.

7 dwg, 8 ex

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RU 2 491 950 C1

Authors

Kozlov Sergej Aleksandrovich

Osmakov Dmitrij Igorevich

Andreev Jaroslav Alekseevich

Koshelev Sergej Gennad'Evich

Grishin Evgenij Vasil'Evich

D'Jachenko Igor' Aleksandrovich

Bondarenko Dmitrij Aleksandrovich

Murashev Arkadij Nikolaevich

Dates

2013-09-10—Published

2012-06-27—Filed