METHOD OF ESTIMATING RISK OF METABOLIC SYNDROME DEVELOPMENT IN CHILDREN BASING ON GENETIC AND BIOCHEMICAL MARKERS Russian patent published in 2013 - IPC G01N33/50 G01N33/92 

FIELD: medicine.

SUBSTANCE: claimed is method of estimating risk of development of metabolic syndrome (MS) in children on the basis of genetic and biochemical markers by presence of insulin-resistance by means of insulin-resistance index HOMA-IR. After analysis of biochemical indices HOMA-IR analysis of atherogenicity coefficient (AC) is carried out. CONCLUSION ABOUT ms development and detection of risk group of disease development among children is made by coefficient 3xCA+HOMA-IR. Range of coefficient values under 10 corresponds to healthy people; from 10 to 14.5 - children with metabolic disorders and obesity; if coefficient is higher than 14.5, MS is diagnosed. In group of children with values, calculated by formula higher than 10, but lower than 14.5, risk of MS is additionally determined by means of method of PCR of methylene tetrahydrofolatereductsase (MTHFR) gene sites with further processing with restriction endonucleases, and if genotype C/T of polymorphous variant 677C/T of MTHFR gene, such children are referred to group of risk of MS development.

EFFECT: efficient method of estimating risk of MS development in children, which makes it possible to start therapeutic and preventive measures at the earliest terms of said disease development.

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