METHOD FOR DETECTING PREDISPOSITION TO THE DEVELOPMENT OF METABOLIC SYNDROME IN THE FORM OF OBESITY IN SCHOOLCHILDREN AGED 7-10 YEARS Russian patent published in 2022 - IPC G01N33/50 G01N33/68 G01N33/49 C12Q1/6806 C12Q1/6827 C12Q1/686 C12Q1/6876 C12Q1/6883 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to pediatrics, pediatric endocrinology, medical genetics, and can be used to identify a predisposition to the development of metabolic syndrome in the form of obesity in schoolchildren 7-10 years old. A sample of buccal epithelium is taken from the patient and DNA is isolated. The polymorphism of the TP53 gene (rs1042522) and the IL1β gene (rs1143634) is genotyped. In a child's blood sample, the content of the transcription factor p53 and the level of interleukin 1β are determined. With the simultaneous fulfillment of the following conditions: the presence of a combination of the GG genotype of the TP53 gene (rs1042522) and the CC genotype of the IL1β gene (rs1143634), a decrease in the level of p53 in the blood compared to the lower limit of the physiological norm, equal to 12-18%, by 1.4 or more times, and an increase in the level of interleukin 1β in comparison with the upper limit of the physiological norm equal to 0-5 pg/cm³, by 1.4 or more times, the predisposition to the development of metabolic syndrome in the form of obesity in schoolchildren 7-10 years old is assessed as high.

EFFECT: method ensures the reliability of revealing predisposition to the development of metabolic syndrome in the form of obesity in schoolchildren aged 7-10 years.

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