FIELD: medicine.
SUBSTANCE: invention refers to medicine, particularly to paediatrics and endocrinology, and aims at determining predisposition to developing obesity in children in conditions of excessive contamination with aluminum. Blood and urine samples are taken in a child. Urine sample is used to determine content of aluminum, and blood serum – IgG level to aluminum. DNA of buccal epithelium is extracted. On the detecting amplifier using polymerase chain reaction in real time genotyping of MTNR1B (rs 10830963) and SIRT1 (rs 7069102) gene polymorphism is carried out. At simultaneous detection of the following diagnostic criteria: presence of variant homozygous or heterozygous genotypes of gene MTNR1B (rs 10830963) and gene SIRT1 (rs 7069102) under condition of simultaneous excess of aluminum concentration in urine by more than 2 times compared to reference level of aluminum content in urine, as well as when the physiological norm of IgG level to aluminum is exceeded in comparison with the upper limit, a conclusion is made on the child's propensity to develop obesity in conditions of excessive contamination with aluminum.
EFFECT: invention provides reliable assessment of aluminum effect on predisposition of manifestations of endocrine disorders in the form of obesity.
1 cl, 2 tbl, 2 ex
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