GENETICALLY MODIFIED NON-HUMAN ANIMALS AND METHOD FOR THEIR APPLICATION Russian patent published in 2018 - IPC A01K67/27 

FIELD: biotechnology.

SUBSTANCE: invention relates to genetic engineering, in particular genetically modified immunodeficient rodent expressing human M-CSF polypeptide, huma IL-3 polypeptide, human GM-CSF polypeptide, human SIRPA polypeptide and human TPO polypeptide. The rodent is modified so that its genome contains nucleic acids encoding human M-CSF, human IL-3, human GM-CSF, human SIRPA and human TPO, respectively. Each of the said nucleic acids is operably linked to a promoter. This invention also discloses a method for engraftment of a hematopoietic stem and progenitor cell (HSPC). This method involves HSPC administration to a genetically modified immunodeficient rodent according to the invention.

EFFECT: invention allows to obtain genetically modified rodents demonstrating improved engraftment of solid tumours for use as models of the human immune system.

19 cl, 17 dwg, 2 ex