FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to biotechnology and virology. The present invention discloses a codon-optimised gene coding the major capsid protein L1 of human papilloma virus which is able for effective expression of the major capsid protein L1 of human papilloma virus after transducing into a yeast cell. What is also described is an immunogenic macromolecule which is preferentially formed by the expression of the above codon-optimising gene coding the major capsid protein L1 of human papilloma virus in the yeast cell. What is also disclosed is using the above immunogenic macromolecule and composition containing the above immunogenic macromolecule.
EFFECT: presented group of inventions may be used in medicine for a human papilloma virus vaccine.
15 cl, 21 dwg, 12 tbl, 22 ex
| Title | Year | Author | Number |
|---|---|---|---|
| RECOMBINANT VACCINE FOR PREVENTION OF HUMAN PAPILLOMAVIRUS INFECTION AND METHOD OF ITS PREPARATION | 2014 |
|
RU2546243C1 |
| PICHIA ANGUSTA RECOMBINANT YEAST STRAIN - PRODUCER OF CAPSID PROTEIN L1 OF HUMAN PAPILLOMAVIRUS TYPE 18 | 2011 |
|
RU2445358C1 |
| PICHIA ANGUSTA RECOMBINANT YEAST STRAIN - PRODUCER OF CAPSID PROTEIN L1 OF HUMAN PAPILLOMAVIRUS TYPE 16 | 2011 |
|
RU2445357C1 |
| NUCLEIC ACID MOLECULE ENCODING HPV 31 L1, EXPRESSION VECTOR, HOST CELL, VIRUS-LIKE PARTICLE AND METHOD OF ITS OBTAINMENT, VACCINE, PHARMACEUTICAL COMPOSITION AND METHODS INVOLVING THEM | 2004 |
|
RU2356943C2 |
| METHOD OF OBTAINING A RECOMBINANT VACCINE FOR PREVENTION OF HUMANPAPILLOMA VIRUS INFECTION, RECOMBINANT VACCINE | 2018 |
|
RU2681174C1 |
| VACCINE COMPOSITION APPLICABLE IN HPV AND HEPATITIS VIRUS INFECTIONS, AND METHOD FOR PREPARING IT | 2009 |
|
RU2509570C2 |
| RECOMBINANT STRAIN OF YEAST Hansenula polymorpha - PRODUCER OF MAJOR CAPSID PROTEIN L1 OF HUMAN PAPILLOMAVIRUS OF TYPE 56 | 2014 |
|
RU2546240C1 |
| OPTIMISED EXPRESSION LI HPV45 IN YEAST | 2004 |
|
RU2360001C2 |
| RECOMBINANT YEAST STRAIN HARSENULA POLYMORPHA - PRODUCER OF THE MAIN CAPCID PROTEIN L1 OF HUMAN PAPILLOMAVIRUS TYPE 11 | 2018 |
|
RU2676160C1 |
| RECOMBINANT YEAST STRAIN HANSENULA POLYMORPHA PRODUCING THE MAIN CAPSID PROTEIN L1 OF HUMAN PAPILLOMAVIRUS TYPE 6 | 2018 |
|
RU2675471C1 |
