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2 494 470

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IPC

G09B23/28(2006-01-01)

A61K38/43(2006-01-01)

A61K47/48(2006-01-01)

A61P11/00(2006-01-01)

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Application

2012113189/14, 2012-04-04

(24)

Start date

2012-04-04

(22)

Actual filing date

2012-04-04

(45)

Published

2013-09-27

(72)

Inventor

Artamonov Andrej VladimirovichBekarev Andrej AleksandrovichDygaj Aleksandr MikhajlovichKinsht Dmitrij NikolaevichMadonov Pavel Gennad'EvichSkurikhin Evgenij GermanovichPershina Ol'Ga ViktorovnaErmakova Natalija Nikolaevna

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennost'Ju F'Jucher Menedzhment" F'Jucher Menedzhment")

METHOD OF TREATING PULMONARY FIBROSIS Russian patent published in 2013 - IPC G09B23/28 A61K38/43 A61K47/48 A61P11/00

Abstract RU 2494470 C1

FIELD: medicine.

SUBSTANCE: hyaluronidase immobilised on polyethylene glycol is introduced into laboratory animals intranasally in a dose of 16 units. Hyaluronidase is introduced once a day on 1^st, 3^rd, 7^th and 10^th day after administering bleomycin that is a pulmonary fibrosis simulation factor.

EFFECT: higher pulmonary tissue resistance to fibrotic depositions, including prevents a reverse process of fibrosis formation ensured by the properties of pegylated hyaluronidase and developed mode of its administration that leads to a prolonged antifibrotic effect with low toxicity and immunogenicity of the effects on the body.

1 ex, 1 tbl

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RU 2 494 470 C1

Authors

Artamonov Andrej Vladimirovich

Bekarev Andrej Aleksandrovich

Dygaj Aleksandr Mikhajlovich

Kinsht Dmitrij Nikolaevich

Madonov Pavel Gennad'Evich

Skurikhin Evgenij Germanovich

Pershina Ol'Ga Viktorovna

Ermakova Natalija Nikolaevna

Dates

2013-09-27—Published

2012-04-04—Filed