FIELD: medicine, pharmaceutics.
SUBSTANCE: prevent invention refers to organic chemistry, namely to new quinolinone derivatives of general formula 
(I) or a pharmaceutically acceptable slat, hydrate or solvate thereof, wherein the above compound contains a flexible fragment specified in a group consisting of amide and an ester, directly conjugated with the substitute R1, and wherein A represents -O-(CH2)n-, wherein n represents an integer from 2 to 4; R1 represents phenyl substituted by one or two substitutes specified in a group consisting of halogen, OH and OCH3; R2, R3, R4 and R5 independently represents hydrogen, C1-4 alkyl or C1-4 alkoxy; R6 represents hydrogen or C1-4alkyl. Also, the invention refers to the compound of formula 
(II) and to a method of treating schizophrenia, acute mania, bipolar disorder or depression.
EFFECT: there are prepared new compounds showing the effective biological properties.
12 cl, 1 tbl, 68 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITIONS, SYNTHESIS AND METHODS OF APPLYING ARYLPIPERAZINE DERIVATIVES | 2010 |
|
RU2506262C2 |
| COMPOSITIONS, SYNTHESIS AND METHODS OF USING INDANONE BASED CHOLINESTERASE INHIBITORS | 2007 |
|
RU2478619C2 |
| METHOD OF PRODUCING, METHODS OF USING AND COMPOSITION OF CYCLOALKYLMETHYLAMINES | 2007 |
|
RU2462451C2 |
| COMPOSITIONS, SYNTHESIS AND METHODS FOR APPLICATION OF PHENYLCYCLOALKYLMETHYLAMINE DERIVATIVES | 2012 |
|
RU2642074C2 |
| PROTEIN TYROSINE KINASE RECEPTOR INHIBITOR COMPOSITIONS | 2009 |
|
RU2586212C2 |
| LEVODOP PRODRUGS, BASED ON THEM COMPOSITIONS AND THEIR APPLICATION | 2005 |
|
RU2365580C2 |
| NEW COMPOUNDS FOR TREATING DISEASES, ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS | 2011 |
|
RU2603008C2 |
| NOVEL HETEROCYCLIC COMPOUNDS AS BRD4 INHIBITORS | 2016 |
|
RU2721120C2 |
| ESTROGEN RECEPTOR PROTEOLYSIS MODULATORS AND RELATED USES THEREOF | 2018 |
|
RU2797808C2 |
| TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DESTROYERS | 2017 |
|
RU2797244C2 |
