FIELD: biotechnology.
SUBSTANCE: invention is immobilised on a matrix streptokinase which activates plasminogen to plasmin. Such streptokinase is resistant to splitting by plasmin in comparison with the corresponding streptokinase of wild type and comprises an amino acid sequence having asparagine in positions corresponding to positions 85 and 412 in SEQ ID NO:1. The invention also relates to the matrix immobilised by the said streptokinase, the method of production of plasmin, and the set for production of plasmin.
EFFECT: invention enables to maintain the functional characteristics of streptokinase while simultaneous increasing resistance to splitting by plasmin while its immobilisation on the matrix.
8 cl, 7 dwg, 8 ex
